2/6/2024 0 Comments Cag promoter sequence snapgene![]() In addition, an in vivo therapy purpose application always required a more accurate editing. Reducing the amount of the Cas-protein in the cells improved the targeting specificity but affected the efficiency. Although it had been shown that different promoters had different effects on the expression level of the interesting gene in the plasmid vector, the effects of the promoters on CRISPR gene-editing tools, such as editing activity, targeting specificity, transcriptional activation level, and base editing ability, have not been comprehensively elucidated. For example, the enhancer/promoter is a critical element in an expression vector, and the selection of the CAG promoter had been reported to significantly increase the expression and the stability of the transgene in mammalian cells. To achieve high transgene expression levels, several investigations had been reported by optimizing cis-acting elements in plasmid systems. Plasmid vector systems contain cis-acting elements, such as enhancers, promoters, polyadenylation signals, and other expression elements, all of which can affect the expression levels of the transgene. The plasmid vector platform is the most commonly used vector for the expression of the CRISPR-Cas tools, such as the adeno-associated virus (AAV) system, the most widely used viral vector for in vivo gene-editing tools’ delivery. However, the successful application of this versatile technology requires the essential expression of the Cas-nuclease protein, which can be generated by a rational synthetic design of the expression cassettes. The CRISPR-Cas systems have been harnessed as powerful tools for a variety of clinical therapy and basic research, including programmable genome editing, gene activation, live imaging, base editing, and primer editing. The data outlined the properties of the widely used promoters in the CRISPR-Cas12a system, which can be a guide for its applications and can be a useful resource for the gene-editing field. Therefore, CAG is recommended in the CRISPR-Cas12a system for the applications that need a robust editing activity but without size limitation, CMV mostly can be an alternative for CAG when requiring a smaller space, EF1a is similar to PGK with relatively high specificity, but has a smaller size, thus is more suitable for in vivo therapeutic applications. We found that without badly damaging targeting specificity, the CAG promoter-driving Cas12a editor exhibited the most active (efficiency takes as 100%, specificity index = ~ 75%) in genomic cleavage, multiplex editing, transcriptional activation, and base editing, followed by promoter CMV (efficiency = 70 ~ 90% (vs CAG), specificity index = ~ 78%), and then EF1a core and PGK (both efficiency = 40–60%, vs CAG) but with higher specificity (specificity index = ~ 84% and ~ 82%, respectively). Herein, we made a parallel comparison among four commonly used promoters (CAG, ~ 1700 bp EF1a core, ~ 210 bp CMV, ~ 500 bp and PGK, ~ 500 bp) in CRISPR-Cas12a system in mammalian cells to explore the impact of promoters on this powerful tool. The plasmid vector platform is the most commonly used vector for the expression of the versatile CRISPR-Cas technique and the promoter is a crucial element for the expression vector, thus profiling the impact of the promoters on CRISPR editors provides the basic information for the gene-editing toolkits and can be a guideline for its design.
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![]() I'm not convinced it is, but I'd like to get all of your opinions on this.Context - this is regarding a small HVAC comp. Hey all,I got into a conversation recently regarding a small company and discussing if a non-ISP provided Firewall was really required. Are Firewalls Really Necessary For Small Businesses? Security.I’d do searches on Amazon or other retail I used to buy refurbished models,īut they only got me so far. I run with a lean budget which means that most PC and Laptop What is the best resource to find the manufacturer year of a computer? Hardware.Is it okay for an entry level IT Support tech/Help Desk to not know how to script/automate? Question for the experienced IT & Tech Careers.Snap! - First Woman in Space, Quantum Processors, eVTOL Commuting, Voicebox AI Spiceworks Originalsįlashback: June 16, 1784: Holland (The Netherlands) outlaws wearing orange clothing (Read more HERE.)įlashforward: Stardate 47457.1: Captain Picard Day first celebrated (Read m. ![]() Is there anything else I can do? If I connect one computer in my LAN (in wifi) and I connect the ethernet cable from the computer to the NAS i get this configuration: Reset the NAS by default but I just dont want to delete all the configuration done before. I wonder how to get on the NAS to change the parameter assigned before in DHCP instead so that can be recognized now. I got a new router from my provider and the local address is now 192.168.1.X, so obiously now I cannot see the NAS. When I switch one of my radio's to 'my music' it connects to the mac mini and I see the list of artists, albums. I can see on the mac mini that the server is running and that it has indexed the library. I do worry.Hi all, I had a NAS ( synology ds216j ) in my LAN with ip address assigned on 192.168.0.20 I have the UE music library 10.0.4 running on my mac mini OS X yosemite alongside the old Squeezebox server. ![]() A large percentage of my Library seems to be gone. Later I signed out and then signed in with the new Apple ID. After signing in to Apple Music on my iPad Air. If they don’t pivot soon to due process and faith in the system, I think we could have very dark days ahead. Apple Music, iTunes, Library I changed my apple id from an old email address that doesnt exist anymore. “Their current weaponization narrative is dangerous and destabilizing, but seems to reflect the party’s early consensus. “I think the verdict on democracy ultimately comes down to Republican leaders and Republican voters," Jolly said. The article further quotes David Jolly, a former Republican congressman from Florida who left the party during the Trump presidency: Trump’s all-caps assertion that it was merely part of the 'GREATEST WITCH HUNT OF ALL TIME.' It is now an article of faith, a default tactic or both," he wrote. "Few if any of them bothered to wait to read the indictment before backing Mr. "It represents either a validation of the rule-of-law principle that even the most powerful face accountability for their actions or the moment when a vast swath of the public becomes convinced that the system has been irredeemably corrupted by partisanship."īaker goes on to suggest that Trump and some other Republicans have caused the issue to worsen by turning their sights on the DOJ and the FBI. "History’s first federal indictment against a former president poses one of the gravest challenges to democracy the country has ever faced," according to Baker's analysis. Baker has covered the White House under the past five presidents, including all four years that Trump was in office.īaker says that, if Trump winds up in front of a jury for these allegations, "it is no exaggeration to suggest that American justice will be on trial as well." The stakes are high for Trump in a case where he could face years in prison, but there is even more on the line in this case, writes Peter Baker of the New York Times. To access music stored on your computer, you need to download and install the UE Music Library software. Is your network connection unstable or browser outdated I need help. 1 From one day to the other (maybe a windows update was in between, not sure), my PC is currently always (self assigning) getting an IP address configured like this: Automatically configured IPv4-Address: 169.254.168.179 IPv4-Subnet Mask: 255.255.0.0 IPv4-Standard Gateway: IPv4-DHCP-Server: 192.168.1.1 IPv4-DNS-Server: 192.168.1. Friday Grooves by IP ADDRESS by IP ADDRESS published on. Donald Trump and his personal valet aren't the only ones on trial in the criminal case brought against him over alleged mishandling of classified documents, according to a news analysis. IP ADDRESS’s tracks Sunday Soul Session by IP Address by IP ADDRESS published on. 2/6/2024 0 Comments Project office for mac![]() However, many PM software vendors are now designing cloud-based, OS-agnostic solutions so as to reach a greater audience as a result, there are relatively few Mac-only PM tools available in the market. There are some industries, such as software and technology, which tend to lean more heavily on Apple products and find a greater return on investment with native Mac solutions. This means the user interface (UI)-how people experience, interact with and understand the product’s content-remains largely unchanged across Mac devices, so as to deliver a uniform look and feel. Native Mac products are designed to run on the Apple operating system, and provide a consistent user experience across Apple devices. Key Considerations What Is Mac Project Management Software? Is a Cloud-Based PM System Right for You? While Windows products previously dominated the workplace, the increasing popularity of iPhones, iPads and iMacs means that more and more businesses are looking for project management software for Mac devices.Īdditionally, with the prevalence of cloud-based PM platforms (the majority of which can run on any operating system), dedicated Apple users have more options than ever before. Prospective buyers have several purchase considerations, including which operating system (OS) the software supports. Indeed, between 20, the number of first-time, small-business buyers who contacted Software Advice in search of a PM system rose 14 percent. Buyers Guide Last Updated: March 16, 2023īusinesses across industries are increasingly looking to adopt project management (PM) software. 2/5/2024 0 Comments Panther vs steelers scoreThey are also 4-1 in their last five following an ATS win. ![]() The Panthers are 6-1 ATS in their last seven games, including the last four. A lot has happened since September, however, and this is now a team that should be able to cover the three points against Pittsburgh. After being an underdog every week since Week 5, the Panthers find themselves three-point favorites.Įarly in the season, the Panthers were favorites three times and went 0-3 straight up and against the spread. The Panthers have won three of their last four, including two straight. ![]() Interim head coach Steve Wilks has this team playing much better than its 5-8 record. Steelers vs Panthers spread analysisĪs dead as Carolina’s playoff chances seemed to be two months ago, it has a legitimate chance to win the NFC South and get into the postseason. Also, check out our full list of NFL promo codes for 2022. Looking to bet on some NFL action? Here are two of the best bonuses* available:Ī) Panthers to win and Sam Darnold Over 1.5 passing TDs BOOSTED to +320 at Caesars! Bet Nowī) New users at DraftKings can bet $5 and get $150 in free bets! Sign Up Now My best bet: Sam Darnold Under 172.5 passing yards (-115) The Under for his passing yards total is at -115, and I don’t think he’ll come close to 172.5 through the air. That means another subdued performance from Darnold. With the Steelers having trouble stopping the run, look for the Panthers to run constantly with their two running backs. Foreman has 147 carries for 637 yards this season, while Hubbard is averaging 4.5 yards on 55 attempts in 2022. The Panthers are really utilizing the talents of both D’Onta Foreman and Chuba Hubbard right now. The Panthers went from 27th earlier in the year to their current ranking of 13th. ![]() With such consistency, Carolina has improved its rushing offense. This season, Carolina has been through just two. Last year, the team used 14 different combinations on the O-line. The Panthers' offensive line has become arguably the strength of the team, and the results are starting to show. This week probably isn’t the game to look for improvement. The Steelers have given up 110, 146, and 215 yards in their last three games. Luckily for the Pittsburgh Steelers, their run defense has struggled as of late as well. This is due to Carolina becoming a run-heavy team on the ground. ![]() In the two games as Carolina’s starter, Darnold has passed for 164 and 120 yards. It presents an opportunity to fade his total passing yards. Sam Darnold is back to being the starting quarterback but is not the focal point of the offense. They fired head coach Matt Rhule after a 1-4 start, and the team also went through the failed experiment with Baker Mayfield, This has been a season of turmoil for the Carolina Panthers. Steelers vs Panthers picks and predictions They are just a game behind the Tampa Bay Buccaneers and need a win against Pittsburgh to keep up with the Bucs.Ĭan Carolina get its third win in a row, or will Pittsburgh play spoiler and pull off the upset? Find out in our free NFL picks and predictions for Steelers vs. The Panthers seem to hanging in there for a playoff spot in the NFC South. The Steelers have lost four of their last seven, and a loss on Sunday would give head coach Mike Tomlin his first losing record since he took the job in 2007. The Pittsburgh Steelers and Carolina Panthers have identical 5-8 records but are two teams going in different directions. 2/5/2024 0 Comments Freac bad sampling rateThat gives you a spectrum replica centered at 0 Hz, and with some care you may be able to low-pass filter it appropriately. If you want to demodulate the signal using bandpass sampling, you may sample at 5 kHz. If you sample at 6 kHz, you'll get two adjacent rectangles, one at -2 to 0 kHz and another at 0 to 2 kHz. What I'm trying to achieve is either a 256, 288, or 320 bitrate, at a sample rate of 44.1 kHz. I would sample higher than 12 kHz to avoid this. After converting my FLAC to AAC (.mp4) usinf FAAC I ended up with a file that both Virtual DJ and iTunes measure in with a bitrate of 230 kbps, and a sample rate of 96 kHz. Fixed freaccmd randomly failing to process files in rare cases. If you sample at 12 kHz, the rectangular spectrum at 4-6 kHz will be adjacent to a rectangular replica at 6-8 kHz. Fixed output sample rate being limited to 192 kHz. Please post new questions and ideas in the new Discussions area and feel free to start discussions about anything releated to fre:ac and digital audio conversion over there. (Recall that a continuous signal sampled at rate $f_s$ will keep its original spectrum, and in addition its spectrum will be replicated and shifted up and down to all integer multiples of $f_s$.) Saturday, 19 February 2022 17:24 fre:ac's discussion forums are moving to GitHub. That means you shouldn't sample at exactly 4, 6, 8 or 12 kHz. However, these calculations are only valid if there is no signal at the very ends of the spectrum, which is not true in your case. The well-known (bandpass) sampling formulas indicate that, if your purpose is to reconstruct the original signal from its samples, you may sample at either 4 kHz, anywhere between 6 and 8 kHz, or above 12 kHz. ![]() ![]() You don't specify what you intend to do with the samples, but I woudn't sample at either of the two frequencies you're contemplating. So the optimal sampling frequency depends on what you are going to do with the signal. Other parameters are significant as well, such as linearity, monotonicity, noise, distortion, etc. Audio is about more than just sampling rate and bits. Using a low sampling frequency (6 kHz or 4 kHz) that aliases the bands may require more work later if you need to have the band back at the original frequency. But the built-in ADC is probably adequate for phone-quality speech or music played through tinny cheap speakers. If processing is non-linear, it may be possible to avoid aliasing of harmonics by filtering after the non-linear processing with critical sampling the harmonics might alias and contaminate the signal. A Hilbert transformer would have more room for the transition band. While some of the lossy codecs might not sound too bad, particularly the higher bit rate ones, the argument. Things like polynomial interpolation work better because of the more dense sampling. Sampling rate : No of samples per Bit-depth. The problem isn't so much that the signal of interest is. For the same reason that we don't use a sledge-hammer to crack a nut. Another thing to consider in your analysis is the zero order hold (sinc response) and any additional analog filtering placed at the DAC output. Oversampling (or using a higher sampling frequency) also helps. So why is it you just don't use a fast sampling rate all the time. According to Nyquist’s Theorem, for an accurate digital representation of a sound wave, the sample rate must be, at least, two times bigger than the highest frequency going to be recorded. You are generally correct that the 3 dB bandwidth is usually less than half the sampling rate (to ease further filtering requirements). Aliasing can also come from a 'bad' anti-aliasing filter. Sometimes it is useful if the signal is oversampled though. As far as I understand, aliasing comes from the fact, that you use a bad sampling rate. For example filters designed to a performance specification can be lower-order than with a higher sampling frequency. Format : MPEG Audio Format version : Version 2 Format profile : Layer 3 Duration : 30s 348ms Bit rate mode : Constant Bit rate : 32.0 Kbps Channel(s) : 2 channels Sampling rate : 16. Using a small sampling frequency has the benefit that any processing will have less samples that need to be computed per time unit. I checked the media info and eventually noticed that the MP3s had a sampling rate of 16kHz, which is unusual. The first curve is the signal's spectrum before sampling. I tilted the band tops to indicate positive and negative frequencies. As you can see in the illustration below, all of the sampling frequencies $f_s$ = 12 kHz, $f_s$ = 6 kHz, and $f_s$ = 4 kHz will work fine. ![]() ![]() If there is overlap between the images thus created, then there will be information loss. fre:ac 1.1.Sampling is frequency domain convolution by a frequency domain impulse train with the impulses spaced apart by the sampling frequency. This is a service focussing on minor improvements and bug fixes. Fre:ac version 1.1.4 has been released on 14th February 2021. 2/5/2024 0 Comments Highlighter pdfpen![]() ![]() Add, delete, rearrange or rotate PDF pages with ease. Can merge multiple files into one PDF document. press PDFpen and PDFpenPro v13.1 Improves Interactive Performance and OCR for an Upgraded User Experience By Sarah Ewing J05:00 AM Version 13. Review documents with their set of stamps or create custom stamps for any workflow. Add texts to PDFs, insert pop-up notes, and write your thoughts in the margins. Just as with Preview (the 10.6 version at least the 10.5 version was more limited). Highlight the important content to stand out at glance. The heart and soul of PDFpen is marking up and modifying PDFs, starting with a full set of PDF markup tools. Enrich your PDF by linking to other pages or external websites. If Max tries to insert a PDF file into a Word document, it displays just fine if the PDF is a single page. The 3D view is now available in London, NYC, San Francisco and LA, with more cities coming soon. Read 80 user reviews and compare with similar apps on MacUpdate. Insert images- update logos in a contract or add a new graph to a report. Download the latest version of PDFpen for Mac for free. Easily fix typos, update numbers, or add entire paragraphs. Switch between day, night, and sepia mode to improve your reading experience. Search like an expert- in multiple PDFs at once, and even through your notes. You can view PDFs as you want- magazines in a two-page view and compare files with the split view. It is packed with powerful features into a well-designed and intuitive interface that effortlessly breezes through any task. PDF Expert is uniquely fast, reliable, and easy to use. Simple, right Check out our full guide to highlight text in PDFs for a more detailed overview on how to edit, highlight, and change text color in your PDF files. show more What is Foxit PhantomPDF ? Foxit PhantomPDF Pricing All you have to do is click on the ‘ Highlight ’ icon in a PDF viewer of your choice and then simply drag your mouse across the piece of text you want to color. Other essential features include an interactive PDF form generator, PDF file organiser and password protector. Foxit PhantomPDF is compatible with multiple file formats like Excel, PowerPoint, Word, HTML, RTF, texts and images, enabling users to export the whole document or a selected area as per convenience. Large teams can depend on the software to integrate with top-notch content management systems, initiate shared reviews, make use of popular cloud storage and manage feedback accordingly. Users can depend on the same o reflow text across paragraphs, alter document layout, columns and pages, modify text size or font and add multimedia as per convenience. An intuitive PDF editor equipped within Foxit PhantomPDF works like a word processor for the users to indulge in. Besides editing the software can also be used to create, protect, manage, review and share documents on the go. So, we have included a variety of PDF editors that come with varying price tags.Foxit PhantomPDF is an online PDF editor that can be used to edit powerful workflows across web, mobile and desktop interfaces from both home and office. Price: Not everyone wants to or cannot spend around $100 on a PDF editor.You may, indeed, go for a minimal editor, though. On top of the list are Optical Character Recognition and Digital Signing. Feature-rich: The ideal PDF editor shouldhave additional features as well. Mark up documents with highlighting, underscoring and strikethrough Save frequently-used.For instance, there must be a way to password-protect PDF. The PDF editor should have an option to enable the basic security features. Security of the PDF documents is also an important concern.Automated selection recognition is great since it enables easy editing of other components like images, boxes, shapes and signatures. Easy & Advanced PDF Editing is a must-have option in a PDF tool.PDF Annotation and Collaboration: fill and save forms, draw, highlight, number pages (including. We always recommend a UI that works well with single-document and multi-document management. PDFpenPro: Your complete PDF editing toolkit for Mac. It must be non-distracting as well as focused. highlighter pdfpen how to In 4 Simple Steps, I will show you how to use pdfpen 6.apk app on your Phone once you are done downloading it: Step 1: Download the pdfpen 6.apk on your device It is the package file format used by the Android operating system for distribution and installation of mobile apps. The PDF Editor must have a Simple User Interface. ![]() To navigate through the immense collection of options, we had a proper criteria as well. As always, we wanted to pick the best ones. The biggest thing that Adobe Acrobat Reader has going for it is that everything just works smoothly, supporting form-fillable and DRM and password-protected PDFs while offering a variety of view. As we said, there are a huge number of PDF editors for macOS. 2/5/2024 0 Comments Membrane pro mac![]() The membrane attack complex is initiated when the complement protein C5 convertase cleaves C5 into C5a and C5b. These fluid phase complexes do not bind to cell membranes and are ultimately scavenged by clusterin and vitronectin, two regulators of complement. If the pre-MAC complexes of C5b-7, C5b-8 or C5b-9 do not insert into a membrane, they can form inactive complexes with Protein S (sC5b-7, sC5b-8 and sC5b-9). If enough pores form, the cell is no longer able to survive. The ring structure formed by C9 is a pore in the membrane that allows free diffusion of molecules in and out of the cell. This region is homologous to cholesterol-dependent cytolysins from Gram-positive bacteria. MAC is composed of a complex of four complement proteins (C5b, C6, C7, and C8) that bind to the outer surface of the plasma membrane, and many copies of a fifth protein (C9) that hook up to one another, forming a ring in the membrane. C5b-6-7-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The MAC is composed of the complement components C5b, C6, C7, C8 and several C9 molecules.Ī number of proteins participate in the assembly of the MAC. Assembly of the MAC leads to pores that disrupt the cell membrane of target cells, leading to cell lysis and death. Antibody-mediated complement activation leads to MAC deposition on the surface of infected cells. The membrane attack complex ( MAC) or terminal complement complex ( TCC) is a complex of proteins typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is an effector of the immune system. A membrane attack complex attached to a pathogenic cell 2/5/2024 0 Comments Microsoft excel 2016 support![]() xlsx format the labels will be preserved, but won’t display in Excel 2016 or earlier versions. xls format, the labels will be permanently lost. What it means If you save this workbook in. This workbook has label information that will be lost or not visible if the file is saved as an earlier Excel format. Unsupported worksheet features can cause the following compatibility issues, leading to a significant loss of functionality or a minor loss of fidelity. When run automatically, the Compatibility Checker also specifies the version of Excel in which a potential compatibility issue occurs. You can then locate all occurrences of the issue, and get information about ways to resolve the issue. The Compatibility Checker lists the compatibility issues it finds, and provides a Find and Help button for many issues. For information about how to run the Compatibility Checker, see Check an Excel workbook for compatibility with earlier versions of Excel. You can then specify that the Compatibility Checker runs automatically every time that you save that workbook. However, to verify that a workbook is compatible with your current version of Excel, you must run the Compatibility Checker manually the first time you save the workbook. When you save a workbook to an Excel 97-2003 file format, the Compatibility Checker runs automatically. To avoid the loss of data or functionality in an earlier version of Excel, you can then make the necessary changes to your current workbook. When you work in Compatibility Mode or want to save aworkbook to the Excel 97-2003 (.xls) file format, the Compatibility Checker can help you identify issues that may cause a significant loss of functionality or a minor loss of fidelity in the earlier version of Excel. Not all new features are supported in earlier versions of Excel. New features that are not supported in earlier versions of Excel For information, see Convert a workbook to a new file format. If you no longer want to work in Compatibility Mode, you can convert the workbook to the current file format. Unlike other Office programs, such as Word, you cannot manually turn on Compatibility Mode in Excel, and you do not have the option to include any new features when you work in a workbook in Compatibility Mode. xltm), the workbook is saved in Excel 97-2003 file format (.xls), a file format that can be opened by earlier versions of Excel. ![]() Also, instead of using a current file format (.xlsx. In Compatibility Mode, any new or enhanced Excel features are not available, which prevents loss of data and fidelity when the workbook is opened in an earlier version of Excel. ![]() In Excel 2010 and later, when you open a workbook that was created in Excel 97-2003, it is automatically opened in Compatibility Mode, and you see Compatibility Mode in square brackets next to the file name in the Excel title bar. You can then make the necessary changes to avoid the loss of data or fidelity that might occur when that workbook is opened in an earlier version of Excel. Compatibility mode is not available for Excel 2007 workbooks.Ĭheck a workbook for compatibility If you want to work in the current file format but have to share a workbook with people who use earlier versions of Excel, you can check that the data is compatible with earlier versions of Excel. Work in Compatibility Mode You can open a workbook that was created in an earlier version of Excel and work in Compatibility Mode so that the workbook remains in a file format that can easily be opened again in the earlier version. After you have installed a new version of Excel, you may want to know how you can continue to work with workbooks that are created in an earlier version of Excel, how you can keep these workbooks accessible for users who do not have the current version of Excel installed, and how the differences between the versions affect the way that you work.įor backward compatibility with earlier versions of Excel, such as Excel 97-2003, you can use one of two ways to exchange workbooks between the different versions. 2/5/2024 0 Comments Ishowu audio capture ventura![]() When we have gathered sufficient feedback to prove there are no problems we'll update the apps to also intentionally uninstall the old one. We honestly don't see this being something people will do. We don't envisage any problems with the upgrade, but we do always like to make a way out in case something unforseen happens - hence the ability to uninstall and fallback to that older kext driver. 1K 142K views 6 years ago How to Setup the Most Popular Screen Recorders on Mac & PC Quick guide to capturing desktop audio when Screen Recording with Quicktime on the Mac. If you uninstall the new driver, the apps will simply revert to using the older driver. The old 'kext' driver can happily co-exist with the new one, it just isn't used. Thus you can keep both installed if you're worried about something failing (pretty unlikely from our testing so far). The new driver is chosen by the apps, if it is installed. No more installer package + 'allow'ing the kext in system preferences + reboots. Is vastly superior with regard to "install experience".Has more audio Hz options (up to 192Khz at the moment).That means less time to get new stuff/features working. Is faster (less latency, better video/audio sync, better GaragaBand/Logic usage). ![]() Our expectation is an overall better experience, by far. That later feature doesn't exist yet but it gives you an idea that there's more available and more options than we had with the older kext based method.Īt the moment the real impact is a one (1!) minute disruption to your workflow as you install the new driver.
2/5/2024 0 Comments Nba turnover leaders![]() NY: Jimmy Butler has made three 3-pointers tonight, but that shot is not a central component to his game. What on earth are you doing? But he created space and found Grant Williams wide open in the corner for a huge 3.ĬF: Celtics have had great chances here to get the margin under 7, but just can’t get out of their own way. KT: Jaylen pulls up from Steph Curry range. He’s 1 of 7 tonight for just 4 points.ĬR: Butler hits a 3, but Grant Williams answers with a trey of his own. NY: Bam Adebayo has had some good looks but can’t seem to get anything to fall. Maybe they’ll have all of that figured out when they play their next game in October.Įnd of third quarter: Heat 76, Celtics 66 - 10:09 p.m. The Celtics lacked defensive intensity, were befuddled by Miami’s now-familiar zone, and refused to play at a fast pace. Save for Game 6 hero Derrick White, who scored 18 points and singlehandedly pulled the Celtics to within 7 in the third quarter, the rest of the Celtics mostly no-showed, particularly second-team All-NBA forward Jaylen Brown, who shot 8 of 23 and committed 8 turnovers. Jayson Tatum rolled his ankle in the first seconds of the game and was seriously affected, particularly on the defensive end. After winning three straight games to even the series and positioning themselves to become the first team in NBA history to overcome a 3-0 deficit and win a playoff series, the Celtics instead played like the worst version of themselves, as if it were a random January game in Sacramento rather than a chance at history. The Celtics’ quest to avenge last season’s loss in the Finals instead ends a round earlier. Jimmy Butler scored 28 points, Caleb Martin had 26, and the Heat defeated the Celtics, 103-84, in Game 7 of the Eastern Conference finals. We talked about it as a group, about ways to coming out and having that edge at home and being great and getting the crowd to rally behind us.įinn’s final take: The Celtics played like the worst version of themselves - 11:05 p.m.Īnd so the Celtics’ season ends with their worst habits rearing up in their most important game. It’s very disappointing losing these games here. Is there a lesson in losing these games? “This is difficult because this building, for so many years, has been so special. Our group was very professional all year, worked really hard.” In that locker room we dealt with a lot of things. Our guys should hold their heads high because we had a lot of adversity. On not finding consistency: “I’m not going to get caught up in consistency questions and things like that. It’s obviously very disappointing for us right now.” I’m proud of the group, of the growth of our team this year, the type of guys that we have, the leaders that we have in that locker room. “But more than anything I’m proud of the group. We had opportunities, we just couldn’t get it going. I feel like tonight we kind of felt it a little bit. It’s not only physical I feel like, it’s emotional. To go down in the hole 3-0 in that way, there’s a lot that goes to it. |
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